Sialyl-Lewis A

Sialyl-Lewis A

Identifiers
CAS number	92448-22-1
MeSH	sialyl+Lewis+A
Jmol-3D images	Image 1
SMILES O=C(O)[C@@]1(O[C@H]2[C@@H](O)[C@@H](CO)O[C@@H](O[C@H]3[C@H](O[C@H]4[C@@H](O)[C@H](O)[C@H](O)[C@H](C)O4)[C@@H](CO)OC(O)[C@@H]3NC(C)=O)[C@@H]2O)C[C@H](O)[C@@H](NC(C)=O)[C@H]([C@H](O)[C@H](O)CO)O1
Properties
Molecular formula	C₃₁H₅₂N₂O₂₃
Molar mass	820.74 g mol⁻¹
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Sialyl Lewis^A, also known as sialyl Le^A and SLe^A, is a tetrasaccharide carbohydrate that is usually attached to O-glycans on the surface of cells. It is known to play a vital role in cell-to-cell recognition processes.

Occurrence of the Sialyl Lewis ^A antigen, detected with the CA19-9 antibody, is highly correlated advanced epithelial cancers, such as stage III and stage IV colorectal cancers.^[1]

References

^ Matsui T, Kojima T, Suzuki H, Hamajima H, Nakazato H, Ito K, Nakao A, Sakamoto J. (June 2004). "Sialyl Lewisa Expression as a Predictor of the Prognosis of Colon Carcinoma Patients in a Prospective Randomized Clinical Trial". Japanese Journal of Clinical Oncology 34 (10): 588–593. doi:10.1093/jjco/hyh110. http://jjco.oxfordjournals.org/cgi/content/full/34/10/588.

Sialyl-Lewis A

See also

References